Addison’s Disease in Dogs

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Hypoadrenocorticism, also known as Addison’s disease, is an endocrine disorder that occurs most commonly in young to middle-aged female dogs, although male dogs can also develop Addison’s disease. Dogs with hypoadrenocorticism are unable to produce an adequate amount of cortisol, which affects their ability to appropriately respond to stress along with a generalized dysfunction of multiple organ systems. Addison’s disease may also interfere with the ability to regulate important electrolytes, especially sodium and potassium.

Addison’s disease is a potentially life-threatening condition. Understanding the symptoms and the risks, especially in dogs predisposed to developing it, can make the difference between a good prognosis and a poor prognosis.

Signs & Symptoms of Addison’s in Dogs

Symptoms of Addison’s disease vary and are often hard for owners to catch until it’s severe. These may include:

  • Lethargy
  • Vomiting
  • Diarrhea
  • Reduced appetite
  • Weight loss
  • Decreased heart rate
  • Arrhythmias
  • Kidney damage
  • Low blood pressure
  • Dehydration

In many cases, the signs of Addison’s disease can be nonspecific, like lethargy, vomiting, diarrhea, decreased appetite, and weight loss. Dogs with Addison’s disease can also experience decreased heart rates with possible heart arrhythmias, which results in poor circulation, and kidney damage secondary to high potassium levels. Many dogs with acute Addison’s disease also have low blood pressure and dehydration.

Decreased production of mineralocorticoids leads to most of the symptoms of Addison’s disease in dogs. A less common form of Addison’s, called “atypical Addison’s,” results from a drop in production of glucocorticoids, which occurs with decreased production of glucose and increased sensitivity to insulin, resulting in low blood sugar.

Summary

Addison’s disease is a dangerous condition that is often hard to catch until symptoms progress. Dogs with Addison’s can be lethargic and depressed, and fatal kidney damage can also occur.

How Did My Dog Get Addison’s Disease?

Dogs develop Addison’s disease through two main processes: autoimmune disease and decreased ACTH production by the pituitary gland.

Common causes:

  • Autoimmune disease
  • Decreased pituitary gland function
  • Breed predisposition

The primary form of Addison’s disease in dogs is an autoimmune disorder that results in the destruction and atrophy of all three layers of the adrenal cortex. The less common type, atypical Addison’s, is caused by inadequate ACTH production by the pituitary gland, which can have a variety of causes in itself.

Young to middle-aged female dogs have Addison’s disease most commonly, while some breeds are predisposed to it. These include Standard Poodles, Great Danes, West Highland White Terriers, Portuguese Water Dogs, Bearded Collies, and several other breeds. In many cases, however, the cause of Addison’s disease is unknown.

Summary

Dogs can develop Addison’s disease from a few ways, including autoimmune disease, decreased pituitary gland function, and breed predisposition.

Diagnosing Addison’s Disease in Dogs

Addison’s disease in dogs is diagnosed through blood work. Veterinarians look for specific chemistry changes, such as high potassium, low sodium, signs of kidney dysfunction, low blood glucose, metabolic acidosis, an absence of a stress leukogram (CBC), and anemia.

If Addison’s is suspected, some veterinarians will recommend beginning with a baseline cortisol level test, which measures cortisol levels. If the results suggest Addison’s, your veterinarian may suggest confirming the diagnosis with an ACTH stimulation test.

Summary

Veterinarians diagnose Addison’s disease through a series of blood tests. If initial testing points toward Addison’s, your veterinarian may then recommend an ACTH stimulation test, which will yield a definitive diagnosis.

Treating Your Dog for Addison’s Disease

By the time most owners become aware that something is wrong with their dog, Addison’s disease is a medical emergency. An Addisonian crisis, also called an adrenal crisis, requires immediate veterinary attention. Veterinarians begin fluid therapy along with supplemental medications, perform necessary diagnostics, like blood work, and administer a steroid to assist with the initial shock. In severe cases, mineralocorticoid replacement therapy may also be started to help patients with extremely high potassium or low sodium to alleviate the secondary effects. Overall kidney function, electrolytes, and blood glucose are also closely monitored to ensure an appropriate response to therapy.

For long-term treatment of Addison’s disease, your veterinarian may prescribe a mineralocorticoid supplement in the form of an injection of DOCP (desoxycorticosterone pivalate). This injection is administered approximately every three to four weeks based on the dog’s response. Your veterinarian may also measure your dog’s electrolytes during the second injection to assess the response to the treatment and determine the best timespan for future injections.

In addition to the injection, your dog will likely need a daily administration of a steroid called prednisone. This acts as a supplement for the deficient glucocorticoid and helps control clinical signs. Occasionally, dogs do not require this supplementation, although the vast majority do. Your veterinarian will determine whether your dog requires it, and if so, the duration of administration. For example, some dogs require prednisone for the rest of their lives, while others only need it during stressful circumstances, like boarding or surgery.

Is there a cure for Addison’s disease?

No. The goal of treatment for this disease is managing the levels of steroids in the bloodstream to decrease the risk of recurring Addisonian episodes, but there is no cure.

Is Addison’s Disease Contagious For Humans or Other Pets?

Addison’s disease is not contagious to humans or other pets.

What is the cost of treating Addison’s disease?

The cost of treating Addison’s disease will depend on the severity of the initial Addisonian crisis and your dog’s response to medication. You can expect to pay for the initial hospitalization and any complications that arise, like kidney dysfunction, as well as medication. Since Addison’s disease is a lifelong condition, you will most likely be paying for medication and veterinary visits for the remainder of your dog’s life.

Summary

Addison’s disease in dogs often presents with an acute Addisonian crisis. Once the crisis is stabilized, your veterinarian will come up with a treatment plan to keep your dog’s steroid levels within appropriate limits.

Recovery and Management of Addison’s Disease

Recovery from Addison’s disease is dependent on the severity of the case at the time of presentation. Except for severe cases, overall recovery prognosis is positive. You can expect to manage your dog’s Addison’s disease for the rest of his life with medication. Without steroids, dogs relapse, and you will also need to take your dog to the veterinarian for monitoring.

Monitoring consists of checking serum electrolytes (sodium/potassium levels) along with standard blood work. These tests check to see if the medication is at an appropriate dose or if adjustments need to be made. Once your dog is stabilized, veterinarians recommend measuring electrolyte levels every three months for the first year after diagnosis and regular check-ups every three to six months.

Summary

Addison’s disease is a lifelong condition that requires careful monitoring, medication, and owner education to prevent a relapse.

Preventing Addison’s Disease

Unfortunately, Addison’s disease cannot be prevented, except in rare cases where it is the result of a prolonged accidental dose of an adrenal enzyme inhibitor like trilostane, in which case correcting the dosage will prevent an Addisonian episode.

Is there a vaccine for Addison’s disease?

Addison’s disease is an autoimmune condition. There is no vaccine.

Summary

Addison’s disease cannot be prevented. However, understanding the signs, symptoms, and treatment options will help you get your dog the veterinary care he needs to give him the best prognosis for his condition.

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